1. List and describe the structure, functions and locations of the skeletal system.
2. List the major cartilages of the human skeleton.

1. Describe the structural components of long bones.
2. Define and describe the membranes of the bone (periosteum and endosteum).

1. Describe the organic components of bone.
2. Describe the inorganic components of bone.

1. Define intramembranous ossification.
2. List and describe the steps of intramembranous ossification.
3. Give examples of bones that develop by intramembranous ossification.
4. Define endochondral ossification.
5. List and describe the steps of endochondral ossification.
6. Give examples of bones that develop by endochondral ossification.

1. Define interstitial growth.
2. Describe the steps of interstitial (in length) growth.
3. Define and describe appositional (in width) growth.

1. Explain how hormones regulate bone growth
   1. Growth hormone (GH)
   2. Thyroid hormones (T₃ and T₄)
   3. Sex hormones (testosterone and estrogens)

1. Describe the functions of osteoblasts, osteoclasts, osteocytes (bone cells) in bone deposit and resorption.
2. Describe how hormones regulate bone remodeling.
3. Describe how mechanical stress influences bone remodeling.
4. Describe the steps of bone simple fracture repair.

Homeostatic Imbalances

1. Describe the following bone disorders:
   1. Osteomalacia
   2. Osteoporosis
   3. Rickets
   4. Paget's disease