BIOL 230 Lecture Guide - Flash Animation: Mode of Action of Macrolides A

Mode of Action of Macrolides in Blocking
Translation during Bacterial Protein Synthesis: Blocking Peptidyltransferase

The macrolides (erythromycin, azithromycin, clarithromycin, dirithromycin, troleandomycin, etc.) bind reversibly to the 50S subunit.They can inhibit elongation of the protein by the peptidyltransferase, the enzyme that forms peptide bonds between the amino acids.

Mode of Action of Macrolides in Blocking Translation during Bacterial Protein Synthesis: Blocking Peptidyltransferase

Mode of Action of Macrolides in Blocking
Translation during Bacterial Protein Synthesis: Blocking Peptidyltransferase