Self Quiz for Animal Virus Life Cycle: The Life Cycle of HIV

Self Quiz for Animal Virus Life Cycles: The Life Cycle of HIV

Study the material in this section and then write out the answers to these questions.
Do not just click on the answers and write them out. This will not test your understanding of this tutorial.

1.**Describe how the retrovirus HIV-1 accomplishes each of the following steps during its life cycle. (Include the following key words in your description: gp120, CD4, chemokine receptors, gp41, capsid, RNA genome, reverse transcriptase, double-stranded DNA intermediate, provirus, polyproteins, proteases, and budding.)

A. viral attachment or adsorption to the host cell (ans)

B. viral entry into the host cell (ans)

C. viral movement to the site of replication within the host cell and production of a provirus. (ans)

D. viral replication within the host cell (ans)

E. viral assembly or maturation within the host cell and release from the host cell (ans)

2. Name 3 types of cells HIV primarily infects and briefly explain why. (ans)

3. Strains of HIV called R5 viruses adsorb to CD4 molecules and a chemokine receptor called CCR5. These strains of HIV primarily infect cells called _________________. (ans)

4. Strains of HIV called X4 viruses adsorb to CD4 molecules and a chemokine receptor called CXCR4. These strains of HIV primarily infect cells called _________________. (ans)

5. If one could destroy all of the infected white blood cells in a person infected with HIV and then reconstitute the cells by giving a bone marrow transplant from a person homozygous for a deletion mutation in their gene coding for the chemokine receptor CCR5 (he or she can not make CCR5 molecules), describe how this might prevent HIV infection in the person receiving the transplant. (ans)

6. HIV possesses a genome of RNA. How then is HIV able to insert into the DNA of host cells and form a provirus? (ans)

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