Objectives for Animal Viruses Life Cycles: The Life Cycle of HIV

Learning Objectives for "Animal Virus Life Cycles: The Life Cycle of HIV"

After completing this section you should be able to perform the following objectives.

1.**Describe how the retrovirus HIV-1 accomplishes each of the following steps during its life cycle. (Include the following key words in your description: gp120, CD4, chemokine receptors, gp41, capsid, RNA genome, reverse transcriptase, double-stranded DNA intermediate, provirus, polyproteins, proteases, and budding.)

A. viral attachment or adsorption to the host cell

B. viral entry into the host cell

C. viral movement to the site of replication within the host cell and production of a provirus.

D. viral replication within the host cell

E. viral assembly or maturation within the host cell and release from the host cell

2. Name 4 types of cells HIV primarily infects and briefly explain why.

3. Describe the role of chemokine receptors in determining what types of cells HIV preferentially infects.

(*) or (**) = possible discussion question

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