The Innate Immune System: Pattern-Recognition Receptors, Antigen-Nonspecific Antimicrobial Body Chemicals, and Cytokines

Learning Objectives for "The Innate Immune System: Pathogen-Associated Molecular Patterns (PAMPs), Pattern-Recognition Receptors (PRRs), and Cytokines Important in Innate Immunity
2. Pattern-Recognition Receptors (PRRs) "

After completing this section you should be able to perform the following objectives.

1.* State the function of the following as they relate to innate immunity.

A. pattern-recognition receptors (PRRs)

B. endocytic pattern-recognition receptors

C. signaling pattern-recognition receptors

D. toll-like receptors

E. NOD-1 and NOD-2

F. RIG-1

G. mannan-binding lectin

2. Name three endocytic PRRs.

3. Name at least three signaling PRRs found on host cell surfaces.

4. Name at least three signaling PRRs found in the endosomes of phagocytic cells.

5. Name at least three signaling PRRs found on the host cell cytoplasm.

6. Briefly describe the major difference between the effect of the cytokines produced in response to PAMPs that bind to cell surface signaling PRRs and endosomal PRRs.

(*) or (**) = possible discussion question

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