The Adaptive Immune System: Cell-Mediated Immunity: Cytotoxic T-Lymphocyte Defense

Learning Objectives for "The Adaptive Immune System: Cell-Mediated Immunity: Activating Antigen-Specific Cytotoxic T-Lymphocytes (CTLs)"

After completing this section you should be able to perform the following objectives.

1.* The role of cytotoxic T-lymphocytes (CTLs) in body defense.

a. State from what cells cytotoxic T-lymphocytes are derived.

b. Describe how they can react with and destroy virus-infected cells, cells containing intracellular bacteria, and cancer cells without harming normal cells. (Indicate the role of following: TCR, CD4, MHC-I, and peptides from endogenous antigens.)

c. State the mechanism by which cytotoxic T-lymphocytes kill the cells to which they bind. (Indicate the role of the following: perforins, granzymes, caspases, and macrophages in the process.)

4. Briefly describe two ways certain viruses may evade cell-mediated immunity.

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