Fig. 7: Activation of a Naive T8-Lymphocyte by an Antigen-Presenting Dendritic Cell
A naive T8-lymphocyte
uses its TCR and CD4 molecule to bind to a complementary shaped MHC-I molecule
with attached peptide epitope on a dendritic cell. This interaction, along with the
binding of co-stimulatory molecules such as CD40, B7, LFA-3, and ICAM-1 on
the dendritic cell with their complementary ligands on the T8-lymphocyte, activates the
naive T8-lymphocyte enabling it to differentiate into an effector cell called
a cytotoxic T-lymphocyte (CTL).