In the case of T-dependent antigens, an activated T4-helper lymphocyte, by way of its TCR and CD4, binds to the MHC-II/epitope on the activated B-lymphocyte. This, along with costimulatory signals that result from the binding of costimulatory molecules such as CD40 and B7 on the B-lymphocyte with their corresponding ligands on the activated T4-lymphocyte enable the T4-helper cell to release cytokines such as IL-4, IL-5, IL-6, and IL-10. (The subset of T4-lymphocytes that normally interact with B-lymphocytes to promote antibody production are called T_h2 lymphocytes.) These cytokines then bind to cytokine receptors on the activated B-lymphocyte triggering its proliferation into a large clone of identical B-lymphocytes.