Cytokines, such
as IL-2 produced by activated T4-helper lymphocytes, binds to receptors on
the activated T8-lymphocytes. This
enables the activated T8-lymphocytes to proliferate and subsequently differentiate
into effector cells called cytotoxic T-lymphocytes (CTLs). Some T8 lymphocytes
also differentiate into T8-memory cells and T8-suppressor cells.