The Adaptive Immune System: MHC Molecules

Learning Objectives for "The Adaptive Immune System: MHC Molecules"

After completing this section you should be able to perform the following objectives.

1. State which body cells display MHC-I surface molecules and which cells normally display MHC-II surface molecules.

2. Define endogenous antigen and exogenous antigen and state which class of MHC molecule binds each.

3. State which type of T-lymphocyte recognizes epitopes from endogenous protein antigens on MHC-I molecules and which type recognizes epitopes from exogenous protein antigens on MHC-II molecules.

4. State the role of proteasomes in binding of peptides from endogenous antigens by MHC-I molecules.

5. State the role of lysosomes in binding of peptides from exogenous antigens by MHC-II molecules.

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